Synthesizing, Studying Molecular Docking, Characterizing, and Preliminary Evaluating Anti-Bacterial Effects of Derivatives of Serotonin Contain Imidazolidine Ring

This study included synthesis of new serotonin derivatives in which imidazolidine rings are present their structures. The final compounds were synthesized by reaction synthesized
 
 Schiff bases with the glycine (NH2-CH2COOH) presence tetrahydrofuran (THF) as a solvent. identified physical characteristics, FT-IR spectroscopy and 1H- NMR spectroscopy. Biological activities against two Gram negative (Klebsiella E. coli) positive (Streptococcus pyogenes Staphylococcus aureus) bacteria also distinguished. All III(a-d) exhibit moderate on four types comparing activity standard drug (Trimethoprim) but highest these occur Streptococcus least coli. studied for molecular docking to know interaction affinity binding between them bacteria